Introduction: The end of generic nutritional guidelines

For more than half a century, public health guidelines on nutrition have followed a one-dimensional approach. Nutritional pyramids and recommended daily intakes (RDIs) have been designed assuming that the metabolism of all human beings responds with the same mathematical linearity to nutrients. However, daily clinical practice and genomic research have conclusively demonstrated the ineffectiveness of this model: standardized diets fail in more than 80% of cases in the long term, and the prevalence of chronic non-communicable diseases, such as cardiovascular obesity and type 2 diabetes, has continued to rise.

The scientific explanation is as simple as it is compelling: individual responses to food are profoundly heterogeneous. What represents clean and efficient metabolic fuel for one person may constitute a pro-inflammatory stress factor for another, accelerating cellular dysfunction. Faced with this reality, the European Union decided to lead one of the largest scientific initiatives in recent history in the field of preventative health: the Horizon 2020 Preventomics project. This international research consortium has laid the definitive scientific foundations for precision nutrition, demonstrating that it is possible to translate complex biological data into highly effective, personalized nutritional guidelines. Oorenji and Mefood Omics represent the direct realization of this milestone in European science, bringing knowledge from the laboratory to the consumer's plate.

The Horizon 2020 Preventomics project: Cutting-edge European science

The Preventomics project ("Empowering consumers to PREVENT diet-related diseases through OMICS sciences") was funded by the European Commission under the prestigious Horizon 2020 research and innovation program with a budget of more than 8 million euros.

Key objectives and research consortium

The fundamental objective of Preventomics was to develop and clinically validate practical personalized nutrition applications based on omics sciences (genomics, metabolomics, and proteomics), facilitating the prevention of chronic diseases and empowering citizens to adopt sustainable healthy lifestyles. The consortium comprised 19 leading partners from 7 European countries, including prestigious universities, centers of research excellence (such as the Eurecat technology center, which coordinated the project), and innovative biotechnology companies, with significant participation from Spanish institutions such as the University of the Balearic Islands (UIB), CIBERobn, and IDIBGI. Mefood Omics SL was directly integrated into this scientific ecosystem to provide technological and commercial support, translating complex bioinformatics discoveries into an accessible precision consumer product for society.

The individual response to nutrients as a paradigm

Preventomics started from a revolutionary premise: the nutrition of the future should not be based on generic prohibitions, but on understanding the unique biochemical mechanisms that govern each person's response to nutrients. To achieve this, the researchers thoroughly analyzed the interaction of three critical biological levels:

• Genetic variability (Nutrigenetics): Single nucleotide polymorphisms (SNPs) that influence enzyme speed, lipid transport, and predisposition to inflammation.
• The metabolic profile (Metabolomics): Circulating biomarkers in blood, urine, and saliva that reflect the dynamic and immediate metabolic state of the individual in response to food intake.
• Behavior and Lifestyle (Behavioral Sciences): Physical activity patterns, sleep habits, stress levels, and cognitive biases determine actual adherence to nutritional guidelines.

From metabolic biomarkers to predictive algorithms

The great challenge of precision nutrition is not obtaining biological data (which is relatively affordable today thanks to DNA sequencing and mass spectrometry), but the integrated interpretation of this data to generate coherent dietary recommendations applicable on a daily basis.

Integration of metabolomics, genetics and lifestyle

Preventomics addressed this challenge by developing a sophisticated bioinformatics infrastructure. The project successfully integrated the patient's genotypic information (static and inherited) with their metabolomic profile (dynamic and changing), modulated in turn by their physical activity and sleep data recorded through wearable devices, into a single predictive model.wearables).

This holistic approach allowed for the mapping of an individual's biochemical pathways in real time, precisely identifying their cellular micronutrient needs, their metabolic tolerance to different types of fats and carbohydrates, and their postprandial inflammatory peaks. For example, instead of generically suggesting a low-fat diet, the algorithm analyzes whether the subject presents risk polymorphisms in the APOE gene combined with a high plasma concentration of fasting triglycerides, recommending a specific type of fat (monounsaturated fatty acids from olive oil) over other options that are healthy on paper but genetically contraindicated for their specific metabolic profile.

Clinical validation of personalized diets

Unlike many commercial nutritional tests that lack empirical support, the methodology developed at Preventomics was subjected to rigorous controlled clinical validation trials in three European countries (Spain, Poland and Denmark), involving hundreds of participants with different health profiles (healthy overweight subjects, people with cardiovascular risk and athletes of different levels).

Clinical trials unequivocally demonstrated that participants receiving personalized nutrition plans based on Preventomics' omics algorithms experienced significantly greater improvements in key metabolic parameters (such as reduced visceral fat, improved insulin sensitivity, and decreased biomarkers of systemic inflammation) compared to the control group, which received standard generic Mediterranean dietary guidelines. Furthermore, and very importantly, the personalized group showed substantially greater and longer-lasting adherence to the diet, demonstrating that science-based personalization acts as a powerful psychological motivator for lasting behavioral change.

From the laboratory to the market: The birth of an accessible technology

Cutting-edge science fails to fulfill its social purpose if it remains confined to scientific journal articles and industrial patents inaccessible to the average citizen. Preventomics' true success lies in its technological transfer to the real market.

Oorenji and Mefood Omics: Spin-off and scientific heritage

Mefood Omics SL, under the strategic direction of Dr. Andreu Palou March and in close collaboration with the scientific community involved in the project, undertook the mission of packaging all this European scientific expertise and transforming it into a high-quality, user-friendly consumer product. From this direct scientific heritage comes Oorenji, a digital precision nutrition platform specifically designed to democratize access to genomics and dietary personalization. Oorenji represents the "translation bridge" that transforms complex metabolomics and genetics into daily shopping lists, delicious menus, easy recipes, and practical advice fully aligned with the user's biology.

The role of Artificial Intelligence and bioinformatics

The Oorenji platform uses state-of-the-art Artificial Intelligence algorithms trained on data and scientific findings from the Preventomics consortium. When a user interacts with the Oorenji platform, the AI engine instantly processes their genetic data, symptoms, dietary preferences (vegan, vegetarian, keto, etc.), and health goals.

In a matter of seconds, AI translates this volume of biological data into a dynamic, personalized nutrition plan that adapts weekly to your actual progress, guaranteeing the highest scientific rigor in every ingredient recommendation. This isn't an automatic recipe generator based on fixed templates, but rather a dynamic bioinformatics recommendation system that simulates the reasoning of a multidisciplinary team of elite geneticists, physicians, and nutritionists.

How Preventomics science is applied to your daily diet

The transition from cutting-edge European research to your daily routine with Oorenji is seamless, interactive, and has enormous practical applicability.

Personalized genetic and metabolic profiling

The process begins with a simple, non-invasive DNA test that the user can perform from the comfort of their own home using a saliva sample. Oorenji's precision laboratory analyzes critical genetic variants in key areas of health:

• Cardiovascular health and lipid metabolism: Genes such as APOE, LPL, and FADS1.
• Carbohydrate sensitivity and risk of diabetes: Genes such as TCF7L2, FTO and PPARG.
• Regulation of appetite and eating behavior: Genes such as MC4R, LEPR and TAS2R38 (predisposition to a taste for sweet or bitter).
• Detoxification pathways, oxidative stress, and inflammation: Genes such as GSTP1, SOD2 and IL6.

This genetic profiling is complemented on the platform with an in-depth digital assessment of the user's current health status, lifestyle, and digestive symptoms.

Oorenji software for users and professionals

Once the data is processed, the magic of applied science becomes visible in the Oorenji app. Users receive an interactive nutritional map with clear and intuitive color codes, an optimized weekly menu ingredient by ingredient, and personalized alerts for key nutrients. If their genes indicate low vitamin D absorption or a predisposition to arterial inflammation from saturated fats, Oorenji prioritizes ingredients with high biological density of these specific nutrients and intelligently adjusts the suggested recipes.

Furthermore, through the MyOorenji vertical (https://my.oorenji.com), healthcare professionals have access to this same precision analytics engine, allowing them to digitize their consultations and prescribe guidelines with a level of clinical and scientific rigor unprecedented in the private sector.

Conclusion: A nutritional revolution endorsed by Europe

Precision nutrition is no longer a futuristic science fiction promise, but a solid therapeutic and preventative reality endorsed by the European Union through large-scale projects like Preventomics. Mefood Omics and its Oorenji platform have made it possible for anyone interested in optimizing their health to easily access this level of applied science in a premium way, tailored to their everyday lifestyle.

Investing in understanding your cellular biology, your genetic predispositions, and the true needs of your metabolism is the smartest and most sustainable health decision you can make. Through Oorenji (https://oorenji.com), you have access to Europe's most advanced nutritional technology, allowing you to nourish yourself not according to internet trends, but according to the instruction manual written in your own DNA. Synchronize your diet with your genome and experience the true power of precision nutrition.

Scientific references

• Celis-Morales, C., Lara, J., & Mathers, JC (2015). Personalized nutrition: opportunities and challenges. Proceedings of the Nutrition Society, 74(3), 249-255.
• Celis-Morales, C., Johnsen, NF, Food4Me Study Consortium, … & Mathers, JC (2017). Effect of personalized nutrition on health-related behavior change: evidence from the Food4Me randomized controlled trial. International Journal of Epidemiology, 46(2), 578-588.
• Palou, A., & Palou, M. (2021). Nutrigenomics and nutrigenetics: the clinical translation of precision nutrition. Journal of Clinical Medicine, 10(12), 2611.
• Horizon 2020 Preventomics Consortium. (2022). Integrated multi-omics approach for personalized nutrition and lifestyle interventions in obesity and cardiovascular prevention. European Journal of Clinical Nutrition, 76(4), 512-526.
• Landberg, R., & Mathers, J.C. (2022). Biomarkers and algorithms in the context of personalized nutrition. Genes & Nutrition, 17(1), 10.